Abstract #1118
Early detection of treatment-induced apoptosis in tumors using temporal diffusion spectroscopy MRI
Xiaoyu Jiang 1 , Hua Li 1 , Ping Zhao 1 , H. Charles Manning 1 , Junzhong Xu 1 , and John C. Gore 1
1
Institute of Imaging Science, vanderbilt
university, nashville, Tennessee, United States
The restoration of apoptosis in cancer cells is a
critical strategy in the development of novel
anti-cancer therapies. In vivo detection of apoptosis
may provide early assessment of therapeutic response,
however, none of the current imaging methods have proven
robustly successful in clinics. Apoptosis at early
stages is associated with significant microstructural
variations, including nuclear fragmentation, cytosolic
condensation, and cellular shrinkage. Here we show that
temporal diffusion spectroscopy, a technique that is
capable of characterizing microstructural variations
across intracellular to cellular length scales, can
provide an early, non-invasive and specific detection of
the microstructural variations associated with
treatment-induced apoptosis.
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