Abstract #1096
High-resolution MRI analysis of breast cancer xenografts on the CAM @ 11.7T
Zhi Zuo 1,2 , Tatiana Syrovets 3 , Felicitas Genze 3 , Alireza Abaei 2 , Genshan Ma 4 , Thomas Simmet 3 , and Volker Rasche 1,2
1
Internal Medicine II, University Hospital
Ulm, Ulm, Baden-Wurttemberg, Germany,
2
Core
Facility Small Animal MRI, Medical Faculty, Ulm
University, Ulm, Baden-Wurttemberg, Germany,
3
Institute
of Pharmacology of Natural Products and Clinical
Pharmacology, Ulm University, Ulm, Baden-Wrttemberg,
Germany,
4
Department
of Cardiology, Zhongda Hospital, Medical School of
Southeast University, Nanjing, Jiangsu, China
High-resolution in ovo imaging is employed for
monitoring the growth of human breast cancer cells
grafted on the chorioallantonic membrane of chick
embryos. High-resolution imaging is achieved by using an
age-adopted precooling regime for immobilization of the
chick embryo. The proposed scheme is proven safe for the
chick embryo showing same survival rates as in a control
group. The high-resolution MRI enables quantification of
the tumor xenografts starting from d4 after grafting. A
good correlation between tumor volumes derived by MRI
and the weight of the tumor after extraction is shown.
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