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Abstract #1076

Hyperpolarized 13C diffusion MRS of copolarized pyruvate and fumarate detects evidence for increased lactate export in 8932 pancreas carcinoma cells compared to MCF-7 cells

Benedikt Feuerecker 1 , Markus Durst 2 , Dieter Saur 3 , Marion I Menzel 4 , Markus Schwaiger 1 , and Franz Schilling 1

1 Nuclear Medicine, Technische Universitt Mnchen, Munich, Bavaria, Germany, 2 GE Global Research, Munich, Germany, 3 Internal Medicine, Technische Universitt Mnchen, Munich, Bavaria, Germany, 4 GE Global Research, Garching, Bavaria, Germany

Upregulation of glycolysis in tumors results in increased lactate concentrations in both intra- and extratumoral areas, the latter leading to an acidification of the tumor microenvironment. Hyperpolarized 13C-labelled metabolic tracers can be used to probe fast metabolic pathways in real-time, however little has been known from these measurements about their presence in intra- or extracellular compartments. In this study we demonstrated that a combination of copolarized C-13 labeled pyruvate and fumarate with ADC measurements holds promise for localizing necrosis and assessing lactate export rate, a parameter that has been shown to correlate with tumor aggressiveness.

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