Abstract #1053
Magnetic resonance elastography of slow and fast shear waves illuminates differences in shear and tensile moduli in anisotropic tissue
John L Schmidt 1 , Dennis J Tweten 1 , Maisie M Mahoney 2 , Tally Portnoi 3 , Ruth J Okamoto 1 , Joel R Garbow 4 , and Philip V Bayly 1,2
1
Mechanical Engineering and Materials
Science, Washington University, St. Louis, MO, United
States,
2
Biomedical
Engineering, Washington University, St. Louis, MO,
United States,
3
Electrical
Engineering, Massachusets Institute of Technology,
Cambridge, MA, United States,
4
Biomedical
Magnetic Resonance Laboratory, Department of Radiology,
Washington University, St. Louis, MO, United States
In magnetic resonance elastography (MRE), mechanical
properties are estimated by inversion of shear wave
fields. Tissue properties are usually assumed to be
isotropic and nearly incompressible, so that only one
parameter (shear modulus) is obtained. In fibrous
tissue, such as muscle or CNS white matter, tissue is
anisotropic. The simplest anisotropic model is an
incompressible, transversely isotropic model with three
parameters: shear modulus (_2), shear anisotropy (ϕ)
and tensile anisotropy (ζ). In this study, measurement
of slow and fast shear wave speeds was performed by MRE
of waves at specific angles relative to fiber direction,
allowing estimation of these parameters.
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