Abstract #1045
Gradient Echo Signal Decays in Healthy and Cancerous Prostate at 3T Require a Gaussian Augmentation of the Mono-Exponential (GAME) Model
Pelin Aksit Ciris 1,2 , Robert V. Mulkern 2,3 , Mukund Balasubramanian 2,3 , Ravi T. Seethamraju 4 , Janice Fairhurst 1 , Junichi Tokuda 1,2 , Jonathan Scalera 1,2 , Tobias Penzkofer 1,2 , Fiona Fennessy 2,5 , Ferenc A. Jolesz 1,2 , Clare M. Tempany-Afdhal 1,2 , Ehud Schmidt 1,2 , and Kemal Tuncali 1,2
1
Brigham and Women's Hospital, Boston, MA,
United States,
2
Harvard
Medical School, Boston, MA, United States,
3
Boston
Children's Hospital, Boston, MA, United States,
4
Siemens
Healthcare, Boston, MA, United States,
5
Dana-Farber
Cancer Institute, MA, United States
Hypoxia is prevalent in prostate cancer, and may
indicate cancer aggressiveness. Oxygenation, among many
other factors, can influence gradient-echo signal decay
in the prostate, appropriate characterization of which
is essential for any potential quantitative use. A
standard Mono-Exponential (ME) decay model has shown
promise at 1.5T, however, we report that proper signal
characterization requires a Gaussian Augmentation of the
Mono-Exponential (GAME) decay model at 3T. GAME
characterized signal decays better than or equivalent to
ME everywhere in the prostate. This increases the
potential for determining correlates of the fit
parameters with biomarkers, such as of oxygenation
status.
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