Abstract #1042
Feasibility of Human Lung Ventilation MR Imaging using Naturally-Abundant Xenon with Optimized 3D SSFP
Neil James Stewart 1 , Graham Norquay 1 , Paul David Griffiths 1 , and Jim Michael Wild 1
1
Academic Unit of Radiology, University of
Sheffield, Sheffield, South Yorkshire, United Kingdom
Diagnostic quality lung ventilation imaging with
naturally-abundant hyperpolarized xenon gas has been
demonstrated in healthy normal subjects and a healthy
smoker at 1.5 T and 3 T for the first time. A 3D
steady-state free precession sequence was optimized for
maximal
129
Xe
image SNR via numerical simulations. SNRs of 25 - 40
were routinely achieved for a voxel size 4.2 x 4.2 x
8/10 mm
3
, with ~ 30% improvement at 3 T
versus 1.5 T. Image quality was comparable to that
obtained with 400 mL enriched xenon and 200 mL
3
He,
and was sufficient for identification of minor
ventilation defects.
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