Abstract #1035
Non-contrast enhanced non-invasive detection and follow-up of lung tumors in mice
Andrea Bianchi 1 , Sandrine Dufort 2,3 , Pierre-Yves Fortin 1,4 , Franois Lux 5 , Gerard Raffard 1 , Nawal Tassali 1 , Olivier Tillement 5 , Jean-Luc Coll 2 , and Yannick Crmillieux 1
1
Centre de Rsonance Magntique des Systmes
Biologiques, University of Bordeaux, Bordeaux, Bordeaux,
France,
2
IAB-INSERM
U823, University Joseph Fourier, Grenoble, France,
3
Nano-H,
Saint Quentin Fallavier, France,
4
Institut
de Bio-Imagerie (IBIO) CNRS/UMS 3428, University of
Bordeaux, Bordeaux, France,
5
ILM
UMR 5306, University Lyon 1, Lyon, France
Lung cancer is the leading cause of cancer deaths
worldwide. MRI can play a major role being a noninvasive
imaging technique, characterized by good soft tissue
contrast, high spatial resolution, and absence of
ionizing radiation. We propose here an in vivo MRI
longitudinal study of lung adenocarcinoma detection in
tumor-bearing immunodeficient mice without the use of
contrast agents. Free-breathing Ultra-short Echo Time
(UTE) MRI acquisitions were compared to standard
gradient echo lung MR images using both
respiratory-gated and free-breathing protocols. The
results were validated against Bioluminescence Imaging
(BLI) and histology.
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