Abstract #1007
Quantitative Dynamic Contrast Enhanced MRI in Acute ST-Elevated Myocardial Infarction: Blood Flow, Microvascular Permeability and Interstitial Volume in Infarct and Peri-Infarct Edema
David A Broadbent 1,2 , Ananth Kidambi 2 , Sven Plein 2 , and David L Buckley 1,2
1
Division of Medical Physics, University of
Leeds, Leeds, West Yorkshire, United Kingdom,
2
Multidisciplinary
Cardiovascular Research Centre, University of Leeds,
Leeds, West Yorkshire, United Kingdom
Dynamic Contrast Enhanced MRI has been used to quantify
relative and absolute myocardial blood flow in health
and disease. Measurement of additional parameters,
including microvascular permeability and contrast agent
distribution volumes, through application of a
distributed parameter model, has also previously been
reported. In this work these methods were applied in a
cohort of patients with acute ST-Elevation Myocardial
Infarction (STEMI) to allow assessment of these
physiological parameters in infarcted and peri-infarct
edematous myocardium.
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