Abstract #0982
MR Imaging, targeting and characterization of pulmonary fibrosis using intra-tracheal administration of Gadolinium based nanoparticles
Nawal Tassali 1 , Andrea Bianchi 1 , Franois Lux 2 , Gerard Raffard 1 , Stephane Sanchez 1 , Olivier Tillement 2 , and Yannick Cremillieux 1
1
Centre de Resonance Magnetique des Systemes
Biologiques, CNRS UMR 5536, Universite de Bordeaux,
Bordeaux, France,
2
Institut
Lumire Matire, CNRS UMR 5306, Universite Claude
Bernard, Domaine Scientifique de la Doua, Villeurbane,
France
Pulmonary fibrosis is a lethal disease and models are
critical to develop diagnostic approaches. We
investigated here whether MRI combined with
gadolinium-based nanoparticles can help visualize and
characterize lung fibrosis in mice. Gd-based contrast
agent was intra-tracheally administered in
bleomycin-treated and in healthy mice and UTE-MRI images
were acquired. Signal enhancement (SE),
contrast-to-noise ratio (CNR), and pharmacokinetics of
the nanoparticles in mice lungs were quantified. A SE of
120%, a twofold increase of CNR and a longer elimination
time constant of the nanoparticles were obtained in
bleomycin-treated mice. These findings demonstrate new
imaging protocols for detecting and characterizing
fibrotic tissues.
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