Abstract #0933
In vivo imaging of bound and pore water in tibia and femur using 3D Cones sequences
Jun Chen 1 , Michael Carl 2 , Hongda Shao 1 , Soorena Azam Zanganeh 1 , Eric Chang 1,3 , Christine B Chung 1,3 , Graeme M Bydder 1 , and Jiang Du 1
1
Radiology, University of California, San
Diego, CA, United States,
2
GE
Healthcare, San Diego, CA, United States,
3
Department
of Radiology, VA San Diego Healthcare System, San Diego,
CA, United States
Bound and pore water have been reported to make
different contributions to the mechanical properties of
cortical bone. By using Ultrashort echo time (UTE)
sequences signals from both bound and pore water can be
detected in cortical bone. In this study, tibial and
femoral mid-shafts in healthy volunteers were
respectively imaged with 3D Cones and 3D IR-Cones
sequences, to measure T1 and T2* of bound and pore water
at both sites, and to investigate whether there are
differences between these two sites. High resolution
imaging of the tibia and fermur can be achieved. The
femoral midshaft and tibial midshaft have different MR
properties, including bound and pore water T2*s,
relative fractions, effective T1 of both bound and pore
water, and T1 of bound water.This study suggests that T1
and T2* of bound and pore water in cortical bone can be
measured with 3D Cones and IR-Cones sequences; femoral
and tibial midshafts may have different properties in
healthy volunteers.
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