Abstract #0899
Blood oxygenation, CBF, OEF, and CMRO2 changes during hypercapnia and hyperoxia using pCASL and TRUST MRI
Jeroen C.W. Siero 1 , Carlos C. Faraco 2 , Alex Bhogal 1 , Megan K. Strother 2 , Peiying Liu 3 , Hanzhang Lu 3 , Jeroen Hendrikse 1 , and Manus J. Donahue 2
1
Radiology, University Medical Center
Utrecht, Utrecht, Utrecht, Netherlands,
2
Radiology
and Radiological Sciences, Nashville, Vanderbilt
University School of Medicine, Tennessee, United States,
3
Radiology
Advanced Imaging Research Center, UTSouthwestern Medical
Center, Texas, United States
Here we evaluate the assumption that two common
hypercapnic stimuli (5%CO2; and carbogen) are
iso-metabolic using MRI-based measures of changes in
venous blood oxygenation. Wholebrain CBF (pCASL), and Yv
(TRUST-MRI) changes were measured for
hypercapnic-normoxia, normocapnia-hyperoxia, and
hypercapnic-hyperoxia stimuli allowing calculation of
OEF and CMRO2. After correcting for the plasma-dissolved
arterial and venous O2, no significant differences in
OEF were found between 5%CO2 and carbogen. Significant
CMRO2 decreases from room air were observed only for the
hypercapnic-normoxic condition. We believe these
findings will be of importance for interpreting
calibrated fMRI and BOLD CVR measurements using
hypercapnic or carbogen stimuli.
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