Abstract #0850
Redistribution of Fractional Ventilation after Circumscribed Primary Lung Injury and Atelectasis
Yi Xin 1 , Maurizio Cereda 2 , Hooman Hamedani 1 , Harrilla Profka 1 , Justin Clapp 1 , Stephen Kadlecek 1 , Brian P. Kavanagh 3 , and Rahim R. Rizi 1
1
Radiology, University of Pennsylvania,
Philadelphia, PA, United States,
2
Anesthesiology
and Critical Care, University of Pennsylvania,
Philadelphia, PA, United States,
3
Hospital
for Sick Children, Toronto, Ontario, Canada
Atelectasis and mild local lung injury cause
redistribution of inspired gas to residual ventilated
airspaces, resulting in their over-ventilation and
potentially damaging ventilatory stress. This dynamic
can be spatially evaluated by hyperpolarized 3He
imaging. Hyperpolarized 3He maps of fractional
ventilation (r) demonstrate that recruitment with PEEP
attenuates residual over-ventilation in HCl models of
circumscribed lung injury.
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