Abstract #0840
Adipose Tissue Hydration as a Potential Non-invasive Marker for Adipose Tissue Hypertrophy
Navin Michael 1 , Suresh Anand Sadananthan 1 , Jadegoud Yaligar 2 , Swee Shean Lee 2 , Melvin Khee-Shing Leow 1,3 , Chin Meng Khoo 4 , Eric Yin Hao Khoo 4 , Kavita Venkataraman 5 , Yung Seng Lee 1,6 , Yap Seng Chong 1,7 , Peter D. Gluckman 1 , E. Shyong Tai 4 , and S. Sendhil Velan 2,8
1
Singapore Institute for Clinical Sciences,
A*STAR, Singapore,
2
Singapore
BioImaging Consortium, A*STAR, Singapore,
3
Department
of Endocrinology, Tan Tock Seng Hospital, Singapore,
4
Department
of Medicine, Yong Loo Lin School of Medicine, National
University of Singapore, Singapore,
5
Saw
Swee Hock School of Public Health, National University
of Singapore, Singapore,
6
Department
of Paediatrics, Yong Loo Lin School of Medicine,
Singapore,
7
Department
of Obstetrics & Gynaecology, Yong Loo Lin School of
Medicine, Singapore,
8
Clinical
Imaging Research Centre, A*STAR, Singapore
The ability to measure adipose hypertrophy
in
vivo
is
relevant to better understand the pathophysiology
involved in type 2 diabetes. Traditionally, adipose
tissue hypertrophy has been assessed directly by
histological examination of adipose tissue explants
which is invasive and inconvenient to carry out in large
cohort studies. The current work investigates the use of
adipose tissue hydration, as measured using
1
H
MRS based hydrolipidic ratio, as a noninvasive marker of
adipose tissue hypertrophy, and its association with
serum metabolic parameters, insulin sensitivity, BMI,
adipose depot volumes and ectopic fat infiltration in
liver and skeletal muscle.
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