Abstract #0831
Longitudinal blood-brain barrier permeability, cerebral flood flow, T2 and diffusion changes following mild traumatic brain injury
Wei Li 1,2 , Justin Long 1 , Lora Watts 1 , Qiang Shen 1 , Robert Boggs 1 , Zhao Jiang 1 , Yunxia Li 1 , and Timothy Q. Duong 1,2
1
Research Imaging Institute, University of
Texas Health Science Center at San Antonio, San Antonio,
TX, United States,
2
Ophthalmology,
University of Texas Health Science Center at San
Antonio, San Antonio, TX, United States
We previously reported CBF and vascular reactivity
dysfunction, T2, ADC, and FA abnormality following mild
TBI in a rat model. However, it is unclear how the
widespread blood-brain barrier permeability changes
affect tissue outcome within and lateral to the impact
site. This study evaluated the effects of changes in
blood-brain barrier permeability described as the Ktrans
rate constant on CBF, T2, ADC, and FA diffusion, and by
longitudinally monitoring changes of these parameters in
the tissue within the impact area and its surrounding.
Multimodal MRI measurements were made longitudinally
from 1 hour and up to 7 days post TBI.
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