Abstract #0791
Effects of temporal resolution on DCE-MRI parameter estimation: In-vivo repeatability analysis of lung tumors using retroactively adjustable KWIC reconstruction
Xia Zhao 1,2 , Yiqun Xue 1,2 , Mark Rosen 2 , Hyunseon Kang 3 , Ramesh Rengan 4 , and Heekwon Song 1,2
1
Laboratory for Structural NMR Imaging,
University of Pennsylvania, Philadelphia, PA, United
States,
2
Department
of Radiology, Hospital of University of Pennsylvania,
Philadelphia, PA, United States,
3
MD
Anderson Cancer Center, University of Texas, Houston,
TX, United States,
4
Department
of Radiation Oncology, University of Washington School
of Medicine, Seattle, WA, United States
In this work, we investigate the effects of temporal
resolution on measured tumor perfusion parameters and
also its effects on repeatability on a test-retest
dataset acquired in vivo in patients with lung tumor. We
utilize interleaved radial acquisition (golden angle
view angle increment) along with KWIC reconstruction
which enables different temporal resolutions to be
chosen retrospectively during image reconstruction. Our
results demonstrate that repeatability is relatively
constant up to about 13 sec frame rate (CV ~ 11%). In
agreement with previous simulation studies, K
trans
is
increasingly underestimated at reduced temporal
resolutions.
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