Abstract #0789
Dynamic contrast-enhanced MR imaging in rectal cancer: study of inter-software accuracy and reproducibility using simulated and clinical data
Luc Beuzit 1 , Pierre-Antoine Eliat 2 , Elise Bannier 1,3 , Jean-Christophe Ferr 1,3 , Yves Gandon 1 , Vanessa Brun 1 , and Herv Saint-Jalmes 4,5
1
Radiology, CHU Rennes, Rennes, France,
2
PRISM-Biosit
CNRS UMS 3480, INSERM UMS 018, University of Rennes I,
Rennes, France,
3
Neurinfo
MR imaging platform, University of Rennes I, Rennes,
France,
4
Radiology,
Eugne Marquis Cancer Institute, Rennes, France,
5
LTSI,
UMR 1099, INSERM, University of Rennes I, Rennes, France
Dynamic contrast-enhanced MRI is a promising biomarker
for investigating early tumor response, but is subject
to numerous factors of variation. The purpose of this
study was to assess the potential role of software
packages in this variability. Using an original DICOM
file processing method, we studied the accuracy of
software packages for measuring pharmacokinetic
parameters on simulated data. We showed significant
errors for all five software packages studied, leading
to poor inter-software agreement. A very poor agreement
was observed among the software packages when processing
clinical data consisting of dynamic contrast-enhanced MR
images of rectal tumors.
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