Abstract #0783
Chemical exchange sensitive Spin-lock MRI of deoxyglucose transport and metabolism in brain
Tao Jin 1 , Hunter Mehrens 1 , and Seong-Gi Kim 1,2
1
Department of Radiology, University of
Pittsburgh, Pittsburgh, PA - Pennsylvania, United
States,
2
Center
for Neuroscience Imaging Research, Institute for Basic
Science, SKKU, Suwon, Korea
Recent studies showed an increase of chemical
exchange-sensitive spin-lock (CESL) MRI signal during
administration of 2-deoxy-glucose (2DG). Since this CESL
technique lacks molecular specificity, more studies are
necessary to examine whether the signal change is caused
by the transport and/or the metabolism of 2DG. The
results of our in vivo study show that the CESL signal
induced by administration of 2DG is strongly dependent
on the injecting dose, anethesia level and brain
regions. It likely contains both transport and
metabolisim components and can be used as biomarker for
the studied of both processes.
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