Abstract #0773
Basal ganglia and thalamic volumes with motor and cognitive outcomes in very preterm 7 year old children.
Wai Yen Loh 1,2 , Deanne K Thompson 1,2 , Jeanie LY Cheong 1,3 , Alicia J Spittle 1,3 , Jian Chen 1,4 , Katherine J Lee 1,3 , Terrie E Inder 5 , Alan Connelly 2,3 , Lex W Doyle 1,3 , and Peter J Anderson 1,3
1
Murdoch Childrens Research Institute,
Melbourne, Victoria, Australia,
2
Florey
Institute of Neuroscience and Mental Health, Melbourne,
Victoria, Australia,
3
University of Melbourne,
Melbourne, Victoria, Australia,
4
Monash
University, Melbourne, Victoria, Australia,
5
Brigham
and Women's Hospital, Boston, Massachusetts, United
States
Very preterm survivors (born <32 weeks gestation)
experience motor and cognitive impairments. The basal
ganglia and thalamus are key relay structures within the
brain that modulate motor control and cognition. This
study segmented the basal ganglia (accumbens, caudate,
pallidum and putamen) and thalamus in 154 very preterm
and 36 term children at age 7 years, using T1 images.
Very preterm children had reduced pallidal and thalamic
volumes compared with controls. Volumes in several of
these relay structures were associated with motor
function and IQ in very preterm children. This study
contributes towards understanding the underlying motor
and cognitive deficits observed in very preterm
children.
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