Abstract #0761
Ultra-high field in vivo localized two dimensional correlated MR spectroscopy to probe membrane degradation during progression of Alzheimers disease
A Alia 1,2 and Niels Braakman 1
1
Leiden Institute of Chemistry, Leiden
University, Leiden, South Holland, Netherlands,
2
Institute
of Medical Physics and Biophysics, Leipzig University,
Leipzig, Germany
In this work we present the first in vivo localized two
dimension spectroscopy to unambiguously identify
glycerophospholipids (GPC) and phosphocholine (PC) in
cortex/hippocampus region of mouse brain at 9.4T. The
increase in GPC is an indicator of increased breakdown
of phospholipids in Alzheimers disease. Till now the
detection of phosphocholine and GPC in disease affected
regions in AD brain has not been possible due to lack of
sensitive detection methods. In the same brain region we
visualized amyloid beta plaques by in vivo MRI. Our
results show a clear correlation between plaque
deposition and membrane breakdown in AD mouse brain.
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