Abstract #0756
In vivo 37 Cl MRI of Human Calf Muscle at 7T
Judith Schork 1 , Anna Kollefrath 1 , Manuela B. Rsler 1 , Reiner Umathum 1 , and Armin M. Nagel 1
1
Medical Physics in Radiology, German Cancer
Research Center (DKFZ), Heidelberg, Germany
Chloride (Cl
-
) plays an important role in
several physiological processes. However, due to the
very short transverse relaxation times, quantitative
measurements of
35
Cl
are challenging. Although this isotope exhibits higher
NMR sensitivity than
37
Cl,
the 1.27-fold lower electrical quadrupole moment of
37
Cl
results in longer relaxation times and could offer an
imaging advantage over
35
Cl.
To prove this effect a quadrature birdcage coil for
37
Cl
MRI was built and used for in vivo and phantom
measurements. This work shows the first
37
Cl
in vivo images of a human calf muscle. For comparison of
relaxation times,
35
Cl
MRI was also performed.
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