Abstract #0744
Skeletal muscle tissue characterization by 23 Na NMRS under different vascular filling conditions
Benjamin Marty 1,2 , Teresa Gerhalter 1,2 , Ericky C.A. Araujo 1,2 , Eric Giacomini 3 , and Pierre G. Carlier 1,2
1
NMR laboratory, Institute of Myology, Paris,
France,
2
NMR
laboratory, CEA/I2BM/MIRCen, Paris, France,
3
UNIRS,
CEA/I2BM/NeuroSpin, Gif-Sur-Yvette, France
The sodium ion is involved in a vast number of functions
at the cellular level. Changes in sodium intracellular
concentration or volume fraction indicate disorders that
alter cell function/integrity or that are responsible
for metabolic changes. Inversion-recovery and triple
quantum filtration (TQF) methods have been previously
proposed to discriminate intra- and extracellular Na+
signals. Here, we proposed a
23
Na
MRS protocol to characterize skeletal muscle tissues in
reasonable acquisition times and evaluated the
sensitivity of different parameters (FID signal, TQF
signal, TQF/FID ratio, T1 value, short T2* fraction) to
differentiate various intracellular volume fractions
conditions.
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