Abstract #0742
Simultaneous Muscle Water T2 and Fat Fraction Mapping using Transverse Relaxometry with Stimulated Echo Compensation
Benjamin Marty 1,2 , Pierre-Yves Baudin 3 , Noura Azzabou 1,2 , Ericky C.A. Araujo 1,2 , Pierre G. Carlier 1,2 , and Paulo Loureiro de Sousa 4
1
NMR laboratory, Institute of Myology, Paris,
France,
2
NMR
laboratory, CEA/I2BM/MIRCen, Paris, France,
3
Consultants
for Research in Imaging and Spectroscopy, Tournai,
Belgium,
4
Universit
de Strasbourg, CNRS, ICube, FMTS, Strasbourg, France
Muscle inflammation and fatty infiltrations are
indicators of disease activity and progression in
neuromuscular disorders. They can respectively be
assessed by muscle T2 relaxometry and water/fat
separation techniques. T2 is often derived from
multiecho spin-echo acquisitions and mono-exponential
fitting. However, MSME signal rarely displays a pure
spin-echo decay as it is a mix of refocused echoes and
stimulated echoes. Recently, it has been proposed to
process MSME signal using the Extended Phase Graph (EPG)
algorithm to take into account stimulated echo. Here, we
implemented a multi-component EPG-fitting to
simultaneously quantify the muscle water T2 and fat
fraction from MSME acquisitions.
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