Abstract #0733
MRI and MRS characterization of Crtc1 knock-out mice limbic structures: investigating neurobiology of mood disorders
Antoine Cherix 1 , Jean-Ren Cardinaux 2,3 , Rolf Gruetter 1,4 , and Hongxia Lei 5,6
1
Laboratory for functional and metabolic
imaging (LIFMET), Ecole Polytechnique Fdrale de
Lausanne, Lausanne, Vaud, Switzerland,
2
Center
for Psychiatric Neuroscience (CNP), Centre Hospitalier
Universitaire Vaudois (CHUV), Lausanne, Vaud,
Switzerland,
3
Faculty
of Medicine, University of Lausanne, Lausanne, Vaud,
Switzerland,
4
Department
of Radiology, University of Lausanne, Lausanne, Vaud,
Switzerland,
5
Center
for Biomedical Imaging (CIBM), Ecole Polytechnique
Fdrale de Lausanne, Lausanne, Vaud, Switzerland,
6
Department
of Radiology, University of Geneva, Geneva, Geneva,
Switzerland
MRI and MRS are two techniques that have been
extensively used to study mood disorders. However, a lot
of discrepancies between the studies reflect the lack of
understanding in the pathophysiology of these complex
diseases. We have investigated the volumetric and
metabolic profile in a mouse model of mood disorders
lacking Crtc1 gene. Knock-out animals showed strong
regional dysregulations in their brain metabolism
together with structural changes as compared to
wild-type animals. This study provides a link between a
specific gene and its associated metabolic and
volumetric alterations and will help understanding
further the underlying pathophysiology of mood
disorders.
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