Abstract #0721
Heritability of structural connections from HCP diffusion MRI data
Stamatios N Sotiropoulos 1 , Xu Chen 2 , Stephen M Smith 1 , David C Van Essen 3 , Timothy E Behrens 1 , Thomas E Nichols 2 , and Saad Jbabdi 1
1
FMRIB Centre, University of Oxford, Oxford,
United Kingdom,
2
Department
of Statistics, University of Warwick, Coventry, United
Kingdom,
3
Department
of Anatomy & Neurobiology, Washington University, St
Louis, MO, United States
There is great interest in understanding population
variability of brain connectivity patterns, and the
genetic contributions to this variability. Heritability,
the proportion of variability attributable to genetic
sources, is a quantitative measure that allows the
identification of phenotypes. In this work, we examine
the heritability of structural connections using
diffusion MRI data from the HCP. We compute whole-brain
structural connectivity matrices and infer on
heritability using permutation testing. Importantly, we
localise regions with most heritable connections across
different cortical parcellations and compare to
heritability trends of cortical morphological features.
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