Abstract #0714
Detection of Diffuse Myocardial Fibrosis In Vivo Using Diffusion Tensor Imaging with the Supertoroidal Model
Choukri Mekkaoui 1 , Howard H Chen 2 , Yin-Ching Iris Chen 2 , William J Kostis 2 , Marcel P Jackowski 3 , Timothy G Reese 2 , and David E Sosnovik 2
1
Harvard Medical School - Massachussetts
General Hospital, Boston, MA, United States,
2
Harvard
Medical School-Massachusetts General Hospital, Boston,
MA, United States,
3
University
of So Paulo, So Paulo, Brazil
Left ventricular hypertrophy (LVH) is accompanied by a
diffuse pattern of myocardial fibrosis. The ability of
conventional DTI metrics to detect diffuse fibrosis,
however, remains unclear. Here we show that the toroidal
volume (TV), derived from the supertoroidal model of the
diffusion tensor, provides a sensitive metric of local
diffusivity. DTI was performed in mice with LVH due to
aortic banding. Despite the presence of marked fibrosis,
mean diffusivity (MD) and fractional anisotropy (FA)
remained normal. In contrast, TV was significantly
reduced in the banded mice, demonstrating its
sensitivity and the value of the supertoroidal model in
detecting microstructural changes.
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