Abstract #0699
Manganese PET enables the same contrast as Manganese Enhanced MRI
Galit Saar 1 , Corina M. Millo 2 , Lawrence P. Szajek 2 , Jeff Bacon 2 , Peter Herscovitch 2 , and Alan P. Koretsky 1
1
LFMI/NINDS, NIH, Bethesda, MD, United
States,
2
PET
Department, Clinical Center, NIH, Bethesda, MD, United
States
Manganese has been used as a functional contrast agent
in many pre-clinical MRI studies. However, Mn
2+
cellular
toxicity limits its use as contrast agent in humans to
low concentrations. We studied
51
Mn
(t1/2=46.2min) and
52
Mn
(t1/2=5.6days) for PET imaging in rats and monkeys. We
show that manganese radiotracers give similar contrast
to Mn
2+
in
MRI with accumulation in different tissues following
systemic infusion even at the low concentration used.
52
Mn-PET
can trace olfactory pathways in the brain following
intranasal administration in monkey, similar to MEMRI in
rodents. Manganese PET should allow using the unique
properties of Mn in clinical studies.
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