Abstract #0697
Structural-Physiological Relationships in the Visual System upon Glutamate Excitotoxicity in the Eye using Diffusion Tensor Imaging and Manganese-enhanced MRI
Leon C. Ho 1,2 , Bo Wang 3,4 , Ian P. Conner 3,4 , Yolandi van der Merwe 1,4 , Richard A. Bilonick 3 , Ed X. Wu 2 , Seong-Gi Kim 1,5 , Gadi Wollstein 3 , Joel S. Schuman 3,4 , and Kevin C. Chan 1,3
1
Neuroimaging Laboratory, University of
Pittsburgh, Pittsburgh, Pennsylvania, United States,
2
Department
of Electrical and Electronic Engineering, The University
of Hong Kong, Pokfulam, Hong Kong, China,
3
Department
of Ophthalmology, School of Medicine, University of
Pittsburgh, Pittsburgh, Pennsylvania, United States,
4
Department
of Bioengineering, Swanson School of Engineering,
University of Pittsburgh, Pittsburgh, Pennsylvania,
United States,
5
Center
for Neuroscience Imaging Research, Institute for Basic
Science, Sungkyunkwan University, Suwon, Korea
Excitotoxicity has been linked to the pathogenesis of
ocular diseases and injuries and may involve early
degeneration of both anterior and posterior visual
pathways. To date, the spatiotemporal patterns of
neurodegeneration in the visual system and the
relationships with excitotoxic retinal injury and optic
neuropathy are not fully elucidated. In this study, we
employed DTI and MEMRI to study the microstructural
alterations, anterograde Mn transport and their
correlations along the visual pathway upon
N-methyl-D-aspartate (NMDA)-induced glutamate
excitotoxicity in the eye, in order to determine the
pathophysiological events and structural-physiological
relationships in the injured visual pathways.
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