Abstract #0681
Regional and age-related variations of the healthy spinal cord structure assessed by multimodal MRI (diffusion, inhomogeneous magnetization transfer, ihMT)
Manuel Taso 1,2 , Olivier M. Girard 3,4 , Guillaume Duhamel 3,4 , Arnaud Le Troter 3,4 , Guilherme Ribeiro 3,4 , Thorsten Feiweier 5 , Maxime Guye 3,4 , Jean-Philippe Ranjeva 3,4 , and Virginie Callot 3,4
1
CRMBM-CEMEREM UMR 7339, Aix-Marseille
Universit, CNRS, Marseille, France,
2
LBA
UMR T 24, Aix-Marseille Universit, IFSTTAR, Marseille,
France,
3
CRMBM UMR 7339, Aix-Marseille
Universit, CNRS, Marseille, France,
4
CEMEREM,
Pole d'imagerie mdicale, Hopital la TImone, AP-HM,
Marseille, France,
5
Siemens AG, Healthcare,
Erlangen, Germany
MRI can provide valuable information about spinal cord
(SC) structure. In the current study, we combine
multimodal MRI (DTI and inhomogeneous magnetization
transfer, ihMT) and atlas-based analysis of the derived
parametric data to study: 1) healthy internal SC
structural variations (in terms of myelin and axonal
content at different levels) and 2) impairment occurring
through the lifespan. Thereby, we highlighted vertebral
level and sensory/motor tract-specific SC structure
dependency, as well as demyelination and axonal loss
occurring with age. Altogether, this study also provides
a normative DTI and MT/ihMT database metrics at
different ages, useful for pathological studies (MS,
ALS).
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