Abstract #0650
Correlation of brain atrophy to decreased CBF and CVR in coronary artery disease patients.
Udunna Anazodo 1,2 , Kevin Shoemaker 3 , Neville Suskin 4 , Danny JJ Wang 5 , and Keith S St Lawrence 1,2
1
Lawson Health Research Institute, London,
Ontario, Canada,
2
Medical
Biophysics, Western University, London, Ontario, Canada,
3
School
of Kinesiology, Western University, London, Ontario,
Canada,
4
London
Health Sciences Cardiology Rehabilitation Program,
London, Ontario, Canada,
5
University
of California, Los Angeles, California, United States
The impact of cardiovascular disease on brain structure
and function is not well known. In this study we present
evidence of cortical thinning and cerebral hypoperfusion
in brains of coronary artery disease patients including
area often associated with cognitive function.
Correlation of brain atrophy to hypoperfusion and
decreased vascular dynamics, measured with
cerebrovascular reactivity suggest that vascular disease
can accelerate decline in brain structure and function.
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