Abstract #0648
Cell Volume Fraction (cell density) is Stable despite Cerebral Volume Loss in Normal Human Ageing as Measured by Quantitative Sodium MR Imaging at 9.4Tesla
Elaine H Lui 1,2 , Jonathan Guntin 3 , Saad Jamil 3 , Ziqi Sun 3 , Ian C Atkinson 3 , and Keith R Thulborn 3
1
Radiology, Royal Melbourne Hospital,
University of Melbourne, Parkville, Victoria, Australia,
2
Centre
of Magnetic Resonance Research, University of Illinois
Chicago, Chicago, Illinois, United States,
3
Centre
of Magnetic Resonance Research, University of Illinois
Chicago, Illinois, United States
The age dependence of cell volume fraction (CVF) has
been determined in normal human brain. CVF is derived
from tissue sodium concentration (TSC) measured by
quantitative sodium MRI at 9.4T using the flexible
twisted projection sequence with 3-point calibration and
the two-compartment model of tissue sodium distribution.
Regional analysis provided descriptive statistics of CVF
and voxel number for specified brain regions to use in a
linear correlation analysis of their dependence on age.
CVF remains stable across cognitively normal ageing
despite progressive cerebral volume loss. This
methodology may be useful for monitoring progression of
neurodegenerative diseases prior to clinical
manifestation.
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