Abstract #0637
Fetal Hemodynamics of Intrauterine Growth Restriction by Phase Contrast MRI and MR Oximetry
mengyuan zhu 1,2 , Sujana Madathil 1 , Sarah Keating 3 , Natasha Milligan 1 , Steven Miller 4 , Rory Windrim 5 , Sharon Portnoy 6 , John G. Sled 7 , Christopher Macgowan 7 , John Kingdom 8 , and Mike Seed 1
1
Heart Centre, The Hospital for Sick
Children, Toronto, Ontario, Canada,
2
Institute
of Medical Science, University of Toronto, Toronto,
Ontario, Canada,
3
Pathology & Laboratory
Medicine, Mount Sinai Hospital, Toronto, Ontario,
Canada,
4
Neurology,
The Hospital for Sick Children, Toronto, Ontario,
Canada,
5
Maternal-Fetal Medicine, Mount Sinai
Hospital, Ontario, Canada,
6
Mouse
Imaging Centre, The Hospital for Sick Children, Toronto,
Ontario, Canada,
7
Physiology & Experimental
Medicine, The Hospital for Sick Children, Toronto,
Ontario, Canada,
8
Obstetrics
& Gynaecology, Mount Sinai Hospital, Toronto, Ontario,
Canada
Current monitoring methods for late-onset intrauterine
growth restriction pregnancies suffer from poor
sensitivity and specificity. This study used new MRI
phase contrast and T2 mapping technology to compare
measurements of fetal vessel blood flow and oximetry in
fetuses with and without IUGR. The results show
redistribution of the fetal circulation and hypoxia in
small for gestational age fetuses in keeping with
previous models of placental insufficiency. In addition,
fetal oxygen delivery was strongly correlated with
placental weight. We speculate that MRI may provide a
clinically useful diagnostic tool for identifying IUGR.
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