Abstract #0615
Quantification of mean cell size and intracellular volume fraction using temporal diffusion spectroscopy
Xiaoyu Jiang 1 , Hua Li 1 , Ping Zhao 1 , Jingping Xie 1 , John C. Gore 1 , and Junzhong Xu 1
1
Institute of Imaging Science, vanderbilt
university, nashville, Tennessee, United States
Oscillating gradient spin echo (OGSE) methods have been
used previously to probe variations in tissues at
cellular and subcellular scales, but their ability to
accurately measure larger cell sizes (e.g. than 10 μm)
is limited. Pulse gradient spin echo (PGSE) acquisitions
use long diffusion times and sample the low frequency
region of temporal diffusion spectra. Combinations of
OGSE and PGSE acquisitions can sample a larger region of
temporal diffusion spectra over a broader range of
diffusion times than any single method on its own, and
hence allow an accurate quantification of intracellular
volume fractions and relatively large mean cell sizes.
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