Abstract #0605
Dynamic-Contrast-Enhanced MRI and Dynamic Tensor Imaging (DTI) for the Early Detection of Anti-angiogenic Effect and Vessel Normalization in Human Breast Cancer Treated with Neoadjuvant Chemotherapy
Thian Ng 1,2 , Bo Zhang 3 , Dennis Cheong 4 , Limiao Jiang 5 , Bingwen Zheng 6 , and Soo Chin Lee 7
1
National University of Singapore, S'pore,
Singapore, Singapore,
2
CIRC/A*STAR,
S'pore, Singapore, Singapore,
3
CIRC/A*STAR,
Singapore, Singapore,
4
CIRC/A*STAR, S'pore,
Singapore,
5
NUS/CIRC,
S'pore, Singapore,
6
NUS/NERI,
S'pore, Singapore,
7
NUS,
S'pore, Singapore
This is a clinical trial study on advanced breast
carcinoma using low-dose Sunitinib to 'Normalization'
the microvascular environment to enhance the delivery of
anti-cancer drugs (AC)to the cancer cells. In vivo DCE-MRI
and DTI are used to monitor the perfusion,and 4 other
vessel parameters changes prior to the main course of
chemotherapy to reveal the most sensitive
biomarker(s)with respect to tumor mass by MRI. Other
histological parameters are measured.
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