Abstract #0531
In vivo 19F MRI to Study ERK1 as a Target for Dendritic Cell Migration in High Grade Glioma
Min-Chi Ku 1 , Helmar Waiczies 2 , Andreas Pohlmann 1 , Susanne Wolf 3 , Helmut Kettenmann 3 , Sonia Waiczies 1 , and Thoralf Niendorf 1
1
Berlin Ultrahigh Field Facility (B.U.F.F.),
Max Delbrck Center for Molecular Medicine, Berlin,
Germany,
2
MRI.TOOLS
GmbH, Berlin, Germany, Berlin, Germany,
3
Cellular
Neurosciences, Max Delbrck Center for Molecular
Medicine, Berlin, Germany
Immunotherapy with dendritic cell (DC)-based vaccines
for treating glioma shed light in the treatment of brain
tumors. To access the efficiency of DC vaccine, it is
necessary to monitor the migration of DCs in the CNS or
lymphoid organs. Our goal is to target molecules, which
are involved in regulating DC migration within the
glioma. In this study we showed that 19F/1H MRI can
monitor the migration of DCs and identified ERK1 as a
factor involved in DC migration.
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