Abstract #0520
Diffusion tensor imaging and magnitization transfer parameters correlate with the white matter pathology in mild traumatic brain injury
Tsang-Wei Tu 1 , Rashida A. Williams 2 , Jacob D. Lescher 2 , L. Christine Turtzo 2 , and Joseph A. Frank 2
1
Radiology and Imaging Sciences, National
Institutes of Health, Bethesda, MD - Maryland, United
States,
2
Radiology
and Imaging Sciences, National Institutes of Health,
Maryland, United States
Both DTI and MTR have been shown capable of detecting
white matter abnormalities. This study investigates the
correlations of DTI and MTR parameters to specific
neuropathologies in the time course of rodent weight
drop TBI. Comparable to the previous reports, our
results suggest that AD and FA are sensitive in
reflecting axonal integrity, while RD is able to detect
myelin content. The MTR at 20 ppm shows strong
correlation with the extent of astrogliosis across TBI
time course. Our findings suggest that DTI and MTR are
sensitive to multiple neuropathologies, and maybe useful
in identifying injury status of mild TBI.
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