Abstract #0516
Functional consequences of neurite orientation dispersion and density in humans across the adult lifespan
Arash Nazeri 1,2 , M. Mallar Chakravarty 3,4 , David J. Rotenberg 1 , Tarek K. Rajji 1 , Yogesh Rathi 5 , Oleg V. Michailovich 6 , and Aristotle N. Voineskos 1
1
Centre for Addiction and Mental Health,
Toronto, ON, Canada,
2
Department
of Psychiatry, University of Toronto, Toronto, ON,
Canada,
3
Department
of Psychiatry, McGill University, Montreal, QC, Canada,
4
Cerebral
Imaging Centre, Douglas Institute, Verdun, QC, Canada,
5
Laboratory
of Mathematics in Imaging, Harvard Medical School,
Boston, MA, United States,
6
Department
of Electrical and Computer Engineering, University of
Waterloo, Waterloo, ON, Canada
Post-mortem studies have documented age-related
neocortical dendritic deficits, while compensatory
dendritic changes appear to take place in other regions.
By applying the neurite-orientation dispersion and
density imaging (NODDI) model to multi-shell diffusion
images, we found an in vivo pattern aligned very closely
with the postmortem data indexing neocortical
vulnerability and hippocampal compensation. We further
demonstrated that these microstructural changes have
consequences in cognitive-function, and brain
resting-state networks with known age-related
susceptibility.
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