Abstract #0513
Reduced Connectivity in 7-year-old Preterm Brain Networks Relates to Adverse Perinatal Events, Cognitive and Motor Impairment
Deanne Thompson 1,2 , Jian Chen 1 , Richard Beare 1 , Christopher Adamson 1 , Zohra Ahmadzai 1 , Claire Kelly 1 , Terrie Inder 3 , Lex Doyle 1,4 , Marc Seal 1 , and Peter Anderson 1,5
1
Murdoch Childrens Research Institute,
Parkville, Victoria, Australia,
2
Florey
Institute of Neuroscience and Mental Health, Parkville,
Victoria, Australia,
3
Brigham and Women's
Hospital, Massachusettes, United States,
4
Royal
Women's Hospital, Parkville, Victoria, Australia,
5
Paediatrics,
University of Melbourne, Parkville, Victoria, Australia
We aimed to determine whether adverse perinatal events
had a lasting effect on white matter connectivity in
childhood, and whether difficulties very preterm
children face may be explained by altered connections
within the brain. We identified specific brain networks
where reduced connectivity was associated with lower
gestational age, perinatal infection and brain
abnormality at term, as well as with impaired IQ and
motor functioning at 7 years of age. This study
highlights the importance of prevention or intervention
following perinatal insults, and increases our
understanding of the neurological mechanisms and brain
networks underlying impairments common to very preterm
children.
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