Abstract #0509
White Matter Tract Integrity, Amyloid burden and Structural atrophy in normal aging and Mild Cognitive Impairment: a PET-MRI study.
Ileana O. Jelescu 1 , Timothy M. Shepherd 1 , Dmitry S. Novikov 1 , Yu-Shin Ding 1 , Thomas Koesters 1 , Kent P. Friedman 1 , Jacqueline Smith 1 , James E. Galvin 2 , and Els Fieremans 1
1
Center for Biomedical Imaging, Dept. of
Radiology, NYU Langone Medical Center, New York, New
York, United States,
2
Alzheimer
Disease Center, Depts. of Neurology, Psychiatry and
Population Health, NYU Langone Medical Center, New York,
New York, United States
Along with cortical abnormalities, white matter (WM)
microstructural changes are involved in the pathogenesis
of AD. We estimate WM Tract Integrity (WMTI) metrics
derived from diffusion kurtosis imaging (DKI) in normal
aging and amnestic Mild Cognitive Impairment (aMCI). DKI
and WMTI metrics in WM ROIs spatially connected to the
hippocampus and cortex and/or known to be affected in AD
correlate significantly with transverse measurements of
pathology such as hippocampal atrophy and amyloid
burden. Future work will focus on the chronology of
changes (i.e. whether the earliest changes take place in
the cortex, in the WM or in sub-cortical structures).
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