Abstract #0499
Performance of Bi-Component T2* Fitting of Bound and Pore Bone Water Fractions is Dependent on Field Strength
Alan C. Seifert 1 , Suzanne L. Wehrli 2 , and Felix W. Wehrli 1
1
University of Pennsylvania, Philadelphia,
PA, United States,
2
Children's
Hospital of Philadelphia, Philadelphia, PA, United
States
Discrimination between bound and pore bone water is
vital for quantification of bone matrix density and
porosity. The two main approaches are T2-selective
magnetization preparation and bi-exponential T2*
fitting. T2* of pore water, however, is shortened by
field gradients arising from the difference in
susceptibility between water and bone. We scanned human
cortical bone specimens at 4 field strengths, and
validated bi-exponential fitting against CT porosity
and gravimetrically-determined matrix density. Our
results indicate that T2* bi-exponential fitting of FIDs
may be a suitable method for quantifying bound and pore
water fractions at 1.5T, but may fail at higher field
strengths.
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