Abstract #0481
Neuroimaging based (PET and MR) measurements of cerebral oxygen extraction fraction (OEF) in patients with brain tumors
Parinaz Massoumzadeh 1 , Safa Najmi 2 , Jonathan McConathy 1 , Andrei Vlassenko 1 , An Hongyu 3 , Yi Su 1 , Daniel Marcus 1 , Keith Rich 4 , and Tammie Benzinger 1
1
Mallinckrodt Institute of Radiology,
Washington University in St. Louis, School of Medicine,
St. Louis, Missouri, United States,
2
Department
of of Neurology, Tabriz Medical University, Tabriz, East
Azarbaijan, Iran,
3
Department
of Radiology, University of North Carolina, Chapel Hill,
North Carolina, United States,
4
Neurological
Surgery, Washington University in St. Louis, School of
Medicine, St. Louis, Missouri, United States
Cerebral hypoxia can potentially impact treatment
outcome and brain tumor patient survival. Preliminary
results of a non-contrast oxygen sensitive magnetic
resonance (MR) procedure for measuring brain and brain
tumoral oxygen extraction fraction (OEF) are presented
and compared with the results obtain using
15
O
positron emission tomography (
15
O-PET)
technique. Both MR and
15
O-PET
can measure OEF in brain tumors and in peritumoral
edema, however, BOLD MR fails in regions with signal
loss on SWI or T2*. Both techniques have tremendous
potential and may offer new insight into the underlying
physiology of brain tumors.
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