Abstract #0475
The effect of white matter perfusion on diffusion MRI based microstructural tissue models
Sjoerd B Vos 1 , Andrew Melbourne 1 , Hui Zhang 2 , John S Duncan 3 , and Sebastien Ourselin 1
1
Translational Imaging Group, University
College London, London, United Kingdom,
2
Centre
for Medical Image Computing, University College London,
London, United Kingdom,
3
Department
of Clinical and Experimental Epilepsy, Institute of
Neurology, University College London, London, United
Kingdom
Perfusion in white matter contributes to
diffusion-weighted signal attenuation that is not
modelled in most diffusion MRI based microstructural
tissue models. This effect is present at low b-values
(<300 s/mm2) and microstructural tissue parameters are
influenced by this. Fitting these models, in this case
NODDI, using only data acquired at b-values > 300 s/mm2
removes this effect. Comparisons of NODDI fitting using
multi-shell acquisitions with (b=0,300,700,2500) or
without (b=300,700,2500) data in the low-b regime show
difference in both the isotropic and intracellular
volume fractions. Correlations of NODDI parameters with
IVIM-derived perfusion data confirm the effects
originate, in part, from perfusion.
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