Abstract #0446
The effect of macroscopic field gradients on the simultaneous estimation of reversible and irreversible transverse relaxation rates
Mukund Balasubramanian 1,2 and Robert V. Mulkern 1,2
1
Department of Radiology, Boston Children's
Hospital, Boston, MA, United States,
2
Harvard
Medical School, Boston, MA, United States
Pulse sequences such as GESFIDE and GESSE have enabled
the simultaneous measurement of irreversible and
reversible transverse relaxation rates. Reversible
relaxation is influenced by both macroscopic and
mesoscopic field inhomogeneities, with considerable
interest in separating effects of the former from the
latter. Here, we applied linear macroscopic gradients
during GESSE scans of the knee, where significant
mesoscopic field variations are induced by bone
trabeculae. We find that the sinc-term corrections that
have been proposed are not warranted and that the
recently-observed Gaussian behavior of GESSE time-domain
signals provides a better avenue for factoring out the
effects of macroscopic field variations.
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