Abstract #0444
B 0 Correction for Myelin Water Fraction Imaging Based on Multi-Slice MGRE Acquisitions
Eva Alonso Ortiz 1 , Ives R. Levesque 2,3 , and G. Bruce Pike 4
1
McConnell Brain Imaging Centre, Montreal
Neurological Institute, McGill University, Montreal,
Quebec, Canada,
2
Medical
Physics Unit, Department of Oncology, McGill University,
Montreal, Quebec, Canada,
3
Research
Institute of the McGill University Health Centre, McGill
University, Montreal, Quebec, Canada,
4
Department
of Radiology and Hotchkiss Brain Institute, University
of Calgary, Alberta, Canada
Myelin water fraction (MWF) imaging based on
multi-component (MC) T2 analysis can be used to
quantitatively assess myelin. Recently, multi-gradient
echo (MGRE) sequences have been proposed for MCT2*-based
MWF mapping, due to their fast, whole-brain or
multi-slice imaging capability, low specific absorption
rate (SAR) and short echo spacing (ES). An important
caveat for MGRE imaging is the significant signal loss
caused by magnetic field inhomogeneities (ΔB0), making
proper ΔB0 correction necessary in order to avoid
inaccuracies in MWF maps. We propose a ΔB0 correction
method based on partial fits to MGRE data obtained for
the MWF-mapping itself.
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