Abstract #0431
Diffusion spectrum imaging connectomics: a biomarker for staging in psychotic disorders
Alessandra Griffa 1,2 , Philipp S Baumann 3,4 , Carina Ferrari 3,4 , Tanja Eric 3,4 , Philippe Conus 3,4 , Kim Q Do 3,4 , Jean-Philippe Thiran 1,2 , and Patric Hagmann 1,2
1
Signal Processing Laboratory 5 (LTS5), cole
Polytechnique Fdrale de Lausanne (EPFL), Lausanne,
Switzerland,
2
Department
of Radiology, Lausanne University Hospital (CHUV) and
University of Lausanne, Lausanne, Switzerland,
3
Service
of General Psychiatry and Center for Psychiatric
Neuroscience, Lausanne University Hospital (CHUV) and
University of Lausanne, Lausanne, Switzerland,
4
Naional
Center of Competence in Research (NCCR) SYNAPSY - The
Synaptic Bases of Mental Diseases, Switzerland
Schizophrenia is a severe psychiatric disorder
hypothesized to result from brain connectivity
impairment. According to the concept of clinical staging
in psychotic disorders, brain connectivity might by more
abnormal in more severe stages of the pathology, and
altered connectivity measures might show progressive
changes from prodromal to chronic phase. In this
diffusion spectrum imaging (DSI) study we identify
possible network-based biomarkers of pathology
progression from early psychosis to chronic
schizophrenia stage, compared to healthy subjects.
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