Abstract #0420
Molecular Imaging Studies of a Robust Gd-Sucrose Scaffold Applied to MR-Colonography
Gary V. Martinez 1 , Parastou Foroutan 2 , Valerie E. Moberg 1 , Suryakiran Navath 3 , Roha Afzal 1 , Robert J. Gillies 1 , Eugene A. Mash 3 , and David L. Morse 1
1
Department of Cancer Imaging and Metabolism,
H. Lee Moffitt Cancer Center & Research Institute,
Tampa, Florida, United States,
2
Bruker
Biospin, Billerica, Massachusetts, United States,
3
Department
of Chemistry and Biochemistry, University of Arizona,
Tucson, Arizona, United States
Colorectal cancer (CRC) has a high incidence as it is
the third most common cancer in both males and females,
and the second leading cause of death from cancer in the
United States. Despite these statistics, it is known
that early detection can mitigate the risk and improve
outcome dramatically, if detected early. In this work,
we present an approach that may potentially mitigate all
of the drawbacks of currently existing methods by using
a Gd sucrose scaffold that has a high relaxivity, is
robust and resilient to the GI tract, and may be
administered orally with minimal bowel preparation.
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