Abstract #0403
Free water elimination DTI in preclinical Alzheimer's: evidence for early axonal degeneration
Andrew R. Hoy 1,2 , Sterling C. Johnson 3,4 , Ozioma C. Okonkwo 4,5 , Cynthia M. Carlsson 3,4 , Henrik Zetterberg 6 , Kaj Blennow 7 , Sanjay Asthana 3,4 , Mark A. Sager 4,5 , Andrew L. Alexander 1,8 , and Barbara B. Bendlin 4,5
1
Medical Physics, University of Wisconsin,
Madison, Wisconsin, United States,
2
Medical
Service Corp, United States Navy, Falls Church,
Virginia, United States,
3
Geriatric Research,
Education and Clinical Center, William S. Middleton
Memorial Veteran's Hospital, Madison, Wisconsin, United
States,
4
Wisconsin
Alzheimer's Disease Research Center, University of
Wisconsin, Madison, Wisconsin, United States,
5
Wisconsin
Alzheimer's Institute, University of Wisconsin, Madison,
Wisconsin, United States,
6
Institute
of Neuroscience and Physiology, Department of Psychiatry
and Neurochemistry, University of Gothenberg,
Gothenberg, Sweden,
7
Department
of Clinical Neuroscience, University of Gothenberg,
Gothenberg, Sweden,
8
Waisman
Laboratory for Brain Imaging and Behavior, University of
Wisconsin, Madison, Wisconsin, United States
This study is the first to investigate the association
between CSF markers and white matter microstructure in
an asymptomatic population using the FWE-DTI model. A
targeted tractography method and voxel based analysis
was used to demonstrate a relation between pTau181 and
NFL and the FWE isotropic volume fraction. Given that
tau and NFL are components of the axonal cytoskeleton
our results suggest that f-value may be sensitive to
early axonal degeneration. Our results suggest that
diffusion imaging with FWE may hold promise for early
disease detection, in addition to providing a novel
outcome measure for prevention and treatment trials.
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