Abstract #0395
Probing in vivo T2 relaxation time alterations in the corpus callosum of a mouse model of Alzheimers disease
Firat Kara 1,2 , Steffen Roner 3 , Annemie Van der Linden 1 , Huub J.M. de Groot 2 , and A. Alia 2,4
1
Bioimaging Lab, University of Antwerp,
Antwerp, Belgium,
2
Leiden
Institute of Chemistry, Gorlaeus Laboratoria, Leiden
University, Leiden, Netherlands,
3
Paul
Flechsig Institute for Brain Research, University of
Leipzig, Leipzig, Germany,
4
Institute
of Medical Physics and Biophysics, Leipzig University,
Leipzig, Germany
The transverse relaxation time (T2) measurements are
sensitive to explore subtle microstructural changes in
the corpus callosum. There is an emergent need for new
in vivo non-invasive studies to monitor corpus callosum
(CC) changes longitudinally in order to clarify how and
when the integrity of CC alters in Alzheimers disease
(AD). In this study we probed in vivo T2 changes
longitudinally in the CC of a mouse model of AD with age
and investigated potential biological mechanisms, such
as demyelination, Aβ deposition and gliosis,
contributing alterations in the biophysical environment
of the CC.
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