Abstract #0393
Quantitative MR Imaging of Hepatic Steatosis: Validation in Ex Vivo Human Livers
Peter Bannas 1,2 , Harald Kramer 3 , Diego Hernando 1 , Ashley M Cunningham 4 , Rakesh Mandal 4 , Rashmi Agni 4 , Utaroh Motosugi 1 , Samir D Sharma 1 , Alejandro Munoz del Rio 1 , Luis Fernandez 5 , and Scott B Reeder 1,6
1
Radiology, University of Wisconsin-Madison,
Madison, WI, United States,
2
Radiology,
University Medical Center Hamburg-Eppendorf, Hamburg,
Hamburg, Germany,
3
Radiology,
Ludwig-Maximilians-University Hospital, Munich, Bavaria,
Germany,
4
Pathology,
University of Wisconsin-Madison, Madison, WI, United
States,
5
Surgery,
University of Wisconsin-Madison, Madison, WI, United
States,
6
Medical
Physics, University of Wisconsin-Madison, Madison, WI,
United States
The aim of our study was to validate MRI based
estimation of proton density fat-fraction (PDFF) as an
imaging biomarker of hepatic steatosis. Previous in vivo
studies have compared MRI-PDFF with the current
reference standard histology. However, in these studies
the underlying triglyceride content remained unknown. In
this work, we used ex vivo human livers to compare
MRI-PDFF with histology, MR spectroscopy (MRS) and
biochemical triglyceride extraction as three independent
reference standards. Our results reveal a good
correlation of MRI-PDFF with hepatic triglyceride
concentration, MRS and histological analysis, validating
that MRI-based PDFF is an accurate biomarker of hepatic
steatosis.
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