Abstract #0384
Assessment of the Hepatocyte Fraction for estimation of liver function
TOMOYUKI OKUAKI 1 , Kosuke Morita 2 , Tomohiro Namimoto 3 , Morikatsu Yoshida 3 , Shinya Shiraishi 3 , Yasuyuki Yamashita 3 , and Marc Van Cauteren 1
1
Philips Healthcare, Minato-ku, Tokyo, Japan,
2
Department
of Central Radiology, Kumamoto University Hospital,
Kumamoto, Japan,
3
Department
of Diagnostic Radiology, Faculty of Life Sciences,
Kumamoto University, Kumamoto, Japan
The hepatocyte fraction(HeF) map is calculated from R1
maps acquired using a breathhold Look-Locker sequence
pre and post Gd-EOB-DTPA. Further, the kHep value is
calculated as uptake function. The resulting HeF and
kHep were compared to the results of 99mTc-GSA
scintigraphy. Seventy five patients were classified into
four severity levels based on scintigraphy. The median
values of the HeF of Normal, Mild, Moderate and Severe
were 76.7%, 72.5%, 50.4% and 44.8% respectively. The HeF
and kHep decreased with liver function deterioration.
The HeF is useful for a robust evaluation of liver
function and kHep provides information about hepatic
uptake.
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