Abstract #0368
Combined 19F MRI and CT imaging for the visualization of delayed release of compounds using pH-sensitive polymers coated capsules in vitro and in a hamster animal model
Sayuan Liang 1 , Dominiek Staelens 2 , Bernard Appeltans 3 , Marlies Van de Wouwer 3,4 , Guy Van den Mooter 3 , Gert Van Assche 2 , Greetje Vande Velde 1 , and Uwe Himmelreich 1
1
Department of Imaging & Pathology, KU
Leuven, Leuven, Flemish Brabant, Belgium,
2
Department
of Clinical and Experimental Medicine, KU Leuven,
Leuven, Flemish Brabant, Belgium,
3
Department
of pharmaceutical and pharmacological sciences, KU
Leuven, Leuven, Flemish Brabant, Belgium,
4
PharmAbs,
KU Leuven, Leuven, Flemish Brabant, Belgium
In vivo imaging of controlled release in the
gastrointestinal tract is of major importance to assess
its efficacy. In this study, we establish a dual modal
imaging platform by combining 19F MRI and CT using 19FDG
and BaSO4 as contrast agent respectively which can
provides information on the location, integrity and
release of material from the capsule into the
gastrointestinal tract of small animal models for the
first time.
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